Diabetic eNOS knockout mice develop distinct macro- and microvascular complications
نویسندگان
چکیده
منابع مشابه
Diabetic eNOS-knockout mice develop accelerated retinopathy.
PURPOSE Dysfunction of endothelial nitric oxide synthase (eNOS) has been implicated in the pathogenesis of diabetic vascular complications. This study was undertaken to determine the role of eNOS in the development of diabetic retinopathy (DR), by investigating the functional consequences of its deficiency in the diabetic state. METHODS Diabetes was induced in eNOS-knockout (eNOS(-/-)) and C5...
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ژورنال
عنوان ژورنال: Laboratory Investigation
سال: 2008
ISSN: 0023-6837,1530-0307
DOI: 10.1038/labinvest.2008.23